Kinda tired, and kinda rushed, and kinda "meh," so this'll be quick. Vice Magazine has a 2-page Q&A with the Kaufmeister and it makes for some interesting reading.

One woman that I know thought there was a misogynist quality to the film.
I am the opposite of a misogynist. My friends are all women. I don't even talk to men.(Source)

Ahaha. He also mentions meeting Todd Haynes, who directed Safe, which Charlie once listed as one of his five favourite films. When I read an early draft of Synecdoche some time ago, I kept thinking of that movie.

And another quote:

I was reading this thing online, this thing that came up the other day, about this certain kind of woman who pops up in movies—I forget what they called her—but I think it was in the Onion. They had an article about certain movies that have this character, which is like the free-spirited, kooky woman who only exists in order to teach the man how to live. I was reading this thing and I saw some comments that said, “Well, what about Clementine from Eternal Sunshine?” Then people started arguing about that. 

The article he's talking about is over here.