Human Nature rarely gets a mention when people discuss Charlie K, but the AV Club gave it a second look and wonders what might have been:

So forget, for a moment, the shrug of mild disappointment that greeted Human Nature's release, and contemplate it not as a film that underperformed spectacularly, but rather as a dazzling possibility.

Think about how exciting and surreal the film sounds in abstract: It's a deeply sad comic fable about the nature of civilization, from the wildly acclaimed super-genius behind Being John Malkovich. It features a love quadrangle involving a man who is raised in the wild as an ape, and gets corrupted rather than elevated by his integration into human society (Rhys Ifans); the world's hairiest woman (Patricia Arquette); a tiny-penised scientist intent on teaching table manners to mice (Tim Robbins); and the girliest scientific researcher in existence (Miranda Otto). (Source)

I'll bet most of you didn't know Steven Soderbergh was lined up to direct Human Nature, but decided to make Out of Sight instead. Or that he had David Hyde Pierce, Marisa Tomei and Chris Kattan in mind to star, instead of Robbins, Arquette and Ifans.